Fig. 4

Physiological and functional outcomes following chronic FSK treatment. A Scheme of rat injection plan. Forskolin (FSK) was weekly administrated for two months (25 mg/kg) followed by 2 months of wash-out up to 5 months of age. The rats were then injected for another month with FSK (2,5 mg/kg) up to 6 months and then sacrificed at 7 months. FSK was delivered by intraperitoneal (IP) or subcutaneous (SC) injection. B Body weight. C TA, heart and EDL weights normalized on the cubic tibial length at the end of the treatment. D Maximal force normalized on the cubic tibial length by grip test. E Normalized Maximal torque force. F) Normalized Maximal torque force as function of muscle stimulation frequency