Fig. 3

Increased movement activity in PK007-treated mdx mice. A highlights a significant increase in locomotor movement in the dark cycle between PK007-treated and Vehicle mdx mice over the 10-day treatment period (postnatal 18 to 28 days). ** denotes p value = 0.0014. Error bars represent the standard error of the mean, and an unpaired t-test was used to calculate the p-value. B represents no significant difference in locomotor movement between PK007-treated and Vehicle WT mice in the dark cycle over the 10-day treatment period (postnatal 18 to 28 days) p-value = 0.2735. Error bars represent the standard error of the mean, and an unpaired t-test was used to calculate the p-value. C-E denote the analysis of total movement activity over days 1, 6 and 10 across the four different treatment groups. Total movement activity was analysed at 24 h, the dark cycle (6 pm-6 am), where mice are the most active and the light cycle (6 am-6 pm), where the mice are least active. C, p values denote * = 0.0474, ** = 0.0090. D, * = p < 0.05. E, p values denote as follows: ** = 0.0010, *** = 0.0003 and **** = p < 0.0001. Biological n numbers = 6 between all treatment groups. P-values for panel B were calculated using a 2-way ANOVA with Tukey’s post hoc test