Fig. 3
From: Generation of a novel mouse model of nemaline myopathy due to recurrent NEB exon 55 deletion
Hmz-NebΔExon55 survival and phenotyping. (A) Kaplan-Meier survival analysis comparing Hmz-NebΔExon55n = 10 pooled WT and HET mice to n = 9 Hmz mice demonstrating that survival is reduced in the Hmz animals with a median survival of 139 days. (B) Body weight over time comparing Hmz-NebΔExon55 sex and age matched pooled WT and HET mice to Hmz mice demonstrating a reduction in male and female Hmz mice body weights that is first noted at 3 weeks of age and that persists until at least 26.5 weeks of age (age of last measurement). (C) Photomicrograph comparing a ~ 3-month-old HET (left-brown) and Hmz-NebΔExon55 mouse (HMZ, right-black) depicting HOM animals having a visibly distinct smaller stature. (D) Mouse rearing at 30 and 60 days of age measured through open field testing. Comparison is between Hmz-NebΔExon55 (n = 6) mice and sex and age matched pooled WT and HET mice (30 day n = 12, 60 day n = 11). Hmz mice have a reduction of rearing at both 30 days of age and 60 days of age that is indicative of motor function deficits