Fig. 3

Selenon-deficient zebrafish larvae show decreased activity. (A) 6 dpf WT (blue) and homozygous selenon-KO selenon^cl502/cl502(red) zebrafish larvae were tested for swim activity using an activity monitor and a 90-minute protocol that included vibration (dotted lines) and cycles of alternating light (non-shaded areas) and dark (shaded areas) periods. (B) Quantification of activity assays of WT and homozygous selenon-mutant lines shows decreased total distance swum in SelN-deficient zebrafish larvae when compared to their correspondending WT controls (N = 24). “*” = p < 0.05, “***” = p < 0.001