Fig. 5
From an early age, Sgcd−/− mice have impairments in TA and EDL muscle function. A TA isometric force (force-frequency relationship) measured at different stimulation frequencies (1–200 Hz). Mice were compared at different ages using two-way ANOVA with Tuckey’s multiple comparisons post-test (n = 5). Values represent mean ± SEM; *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, and ****p ≤ 0.0001. B Fatigue and recovery curves of TA muscle were evaluated using two-way ANOVA with Tuckey’s multiple comparisons post-test (n = 5). Values represent mean. C EDL specific (N/cm2) and normalized (N/g) force at both ages (n = 3–4). Values represent mean ± SEM; **p ≤ 0.01. D EDL resistance to mechanical damage by ECC stimulation (n = 3–4). Two-way ANOVA with Šídák multiple comparisons post-test was used to compare mice at each age. Values represent mean ± SEM; *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, and ****p ≤ 0.0001