OBSCN undergoes extensive alternative splicing during human cardiac and skeletal muscle development

Oghabian, Ali; Jonson, Per Harald; Gayathri, Swethaa Natraj; Johari, Mridul; Nippala, Ella; Andres, David Gomez; Munell, Francina; Soriano, Jessica Camacho; Duran, Maria Angeles Sanchez; Sinisalo, Juha; Tolppanen, Heli; Tolva, Johanna; Hackman, Peter; Savarese, Marco; Udd, Bjarne

doi:10.1186/s13395-025-00374-6

Skeletal Muscle

Table 2 The studied OBSCN isoforms and exons

From: OBSCN undergoes extensive alternative splicing during human cardiac and skeletal muscle development

Exon number	Meta transcript exon number	Chr	Begin	End	Strand	ENST00000284548	ENST00000422127	ENST00000493977	ENST00000570156	ENST00000660857	ENST00000680850	First exon	Last exon	Alternative splicing	Start Phase	End Phase	Domain
1	1	chr1	228208044	228208185	+				1		1	TRUE	FALSE		-	-	-
2	1a	chr1	228208063	228208185	+	1						TRUE	FALSE		-	-	-
3	1b	chr1	228208130	228208185	+		1					TRUE	FALSE		-	-	-
4	2	chr1	228211766	228212771	+	2	2		2		2	FALSE	FALSE		-	1	Ig #1, Ig #2, Ig#3
5	3	chr1	228213441	228213710	+	3	3		3		3	FALSE	FALSE		1	1	Ig #4
6	4	chr1	228214174	228214434	+	4	4		4		4	FALSE	FALSE		1	1	Ig #5
7	5	chr1	228214790	228215098	+	5	5		5		5	FALSE	FALSE		1	1	Fn3 #1
8	6	chr1	228215563	228215829	+	6	6		6		6	FALSE	FALSE		1	1	Ig #6
9	6a	chr1	228215689	228215829	+			1				FALSE	FALSE		1	1	Ig #6
10	7	chr1	228216421	228216702	+	7	7	2	7		7	FALSE	FALSE		1	1	Ig #7
11	8	chr1	228217013	228217288	+	8	8	3	8		8	FALSE	FALSE		1	1	Ig #8
12	9	chr1	228217395	228218222	+			4				FALSE	TRUE	AL=chr1:228359597-228361250:+, AL=chr1:228378618-228378874:+, AL=chr1:228378618-228378876:+	1	-	-
13	10	chr1	228219324	228219599	+				9		9	FALSE	FALSE		1	1	Ig #9
14	11	chr1	228224459	228224734	+	9	9		10		10	FALSE	FALSE		1	1	Ig #10
15	12	chr1	228243183	228243458	+	10	10		11		11	FALSE	FALSE		1	1	Ig #11
16	13	chr1	228244296	228244571	+	11	11		12		12	FALSE	FALSE		1	1	Ig #12
17	14	chr1	228245413	228245688	+	12	12		13		13	FALSE	FALSE		1	1	Ig #13
18	15	chr1	228246528	228246803	+	13	13		14		14	FALSE	FALSE		1	1	Ig #14
19	16	chr1	228249965	228250240	+	14	14		15		15	FALSE	FALSE		1	1	Ig #15
20	17	chr1	228256651	228256926	+	15	15		16		16	FALSE	FALSE		1	1	Ig #16
21	18	chr1	228259501	228259776	+				17		17	FALSE	FALSE		1	1	Ig #17
22	19	chr1	228264116	228264391	+	16	16		18		18	FALSE	FALSE		1	1	Ig #18
23	20	chr1	228268530	228268805	+	17	17		19		19	FALSE	FALSE		1	1	Ig #19
24	21	chr1	228271925	228272221	+				20		20	FALSE	FALSE		1	1	Ig #20
25	22	chr1	228273272	228273547	+				21		21	FALSE	FALSE		1	1	Ig #21
26	23	chr1	228273770	228274048	+	18	18		22		22	FALSE	FALSE		1	1	Fn3 #2
27	24	chr1	228274178	228274444	+	19	19		23		23	FALSE	FALSE		1	1	Ig #22
28	25	chr1	228274572	228274841	+	20	20		24		24	FALSE	FALSE		1	1	Ig #23
29	26	chr1	228275760	228276026	+	21	21		25		25	FALSE	FALSE		1	1	Ig #24
30	27	chr1	228276450	228276716	+	22	22		26		26	FALSE	FALSE		1	1	Ig #25
31	28	chr1	228276930	228277042	+	23	23		27		27	FALSE	FALSE		1	0	½ Ig #26
32	29	chr1	228277160	228277313	+	24	24		28		28	FALSE	FALSE		0	1	½ Ig #26
33	30	chr1	228277505	228277666	+				29		29	FALSE	FALSE		1	1	½ Ig #27
34	31	chr1	228277754	228277858	+	25	25		30		30	FALSE	FALSE		1	1	½ Ig #27
35	32	chr1	228278689	228278955	+	26	26		31		31	FALSE	FALSE		1	1	Ig #28
36	33	chr1	228279175	228279444	+	27	27		32		32	FALSE	FALSE		1	1	Ig #28 few AAs
37	34	chr1	228279821	228280087	+	28	28		33		33	FALSE	FALSE		1	1	Ig #29
38	35	chr1	228280179	228280445	+	29	29		34		34	FALSE	FALSE		1	1	Ig #30
39	36	chr1	228280530	228280796	+	30	30		35		35	FALSE	FALSE		1	1	Ig #31
40	37	chr1	228281933	228282205	+	31	31		36		36	FALSE	FALSE		1	1	Ig #32
41	38	chr1	228283018	228283284	+	32	32		37		37	FALSE	FALSE		1	1	Ig #33
42	39	chr1	228283503	228283769	+	33	33		38		38	FALSE	FALSE		1	1	Ig #34
43	40	chr1	228286078	228286350	+	34	34		39		39	FALSE	FALSE		1	1	Ig #35
44	41	chr1	228286773	228287039	+	35	35		40		40	FALSE	FALSE		1	1	Ig #36
45	42	chr1	228287694	228287960	+	36	36		41		41	FALSE	FALSE		1	1	Ig #37
46	43	chr1	228288061	228288324	+	37	37		42		42	FALSE	FALSE		1	1	Ig #38
47	44	chr1	228288625	228288888	+	38	38		43		43	FALSE	FALSE		1	1	Ig #39
48	45	chr1	228291898	228292161	+	39	39		44		44	FALSE	FALSE		1	1	Ig #40
49	46	chr1	228292523	228292786	+	40	40		45		45	FALSE	FALSE		1	1	Ig #41
50	47	chr1	228293353	228293616	+	41	41		46		46	FALSE	FALSE		1	1	Ig #42
51	48	chr1	228294152	228294415	+	42	42		47		47	FALSE	FALSE		1	1	Ig #43
52	49	chr1	228294780	228295043	+	43	43		48		48	FALSE	FALSE		1	1	Ig #44
53	50	chr1	228298454	228298717	+				49		49	FALSE	FALSE		1	1	Ig #45
54	51	chr1	228299259	228299522	+				50		50	FALSE	FALSE		1	1	Ig #46
55	52	chr1	228299882	228300145	+				51		51	FALSE	FALSE		1	1	Ig #47
56	53	chr1	228303675	228303938	+				52		52	FALSE	FALSE		1	1	Ig #48
57	54	chr1	228304303	228304566	+				53		53	FALSE	FALSE		1	1	Ig #49
58	55	chr1	228305123	228305386	+				54		54	FALSE	FALSE		1	1	Ig #50
59	56	chr1	228306372	228306638	+	44	44		55		55	FALSE	FALSE		1	1	Ig #51
60	57	chr1	228306901	228307167	+	45	45		56		56	FALSE	FALSE		1	1	Ig #52
61	58	chr1	228307259	228307531	+	46	46		57		57	FALSE	FALSE		1	1	Ig #53
62	59	chr1	228308111	228308383	+	47	47		58		58	FALSE	FALSE		1	1	Ig #54
63	60	chr1	228309099	228309295	+	48	48		59		59	FALSE	FALSE		1	0	½Ig #55
64	61	chr1	228309484	228309559	+	49	49		60	1	60	FALSE	FALSE		0	1	½Ig #55
65	62	chr1	228313614	228313886	+					2		FALSE	FALSE		1	1	Ig #56
66	63	chr1	228314814	228315080	+					3		FALSE	FALSE		1	1	Ig #57
67	64	chr1	228315847	228316119	+	50	50		61	4	61	FALSE	FALSE		1	1	Ig #58
68	65	chr1	228316709	228316984	+	51	51		62		62	FALSE	FALSE		1	1	Ig #59
69	66	chr1	228317464	228317751	+	52	52		63		63	FALSE	FALSE		1	1	Fn3
70	67	chr1	228317892	228318173	+	53	53		64		64	FALSE	FALSE		1	1	Ig #60
71	68	chr1	228318884	228319254	+	54	54		65		65	FALSE	FALSE		1	0	-
72	69	chr1	228321344	228322214	+	55	55		66		66	FALSE	FALSE		0	1	IQ, Ig #61
73	70	chr1	228323328	228323606	+	56	56		67		67	FALSE	FALSE		1	1	Ig #62
74	71	chr1	228332860	228332938	+	57	57		68		68	FALSE	FALSE		1	2	-
75	72	chr1	228333199	228333323	+	58	58		69		69	FALSE	FALSE		2	1	½ Ig #63
76	73	chr1	228333583	228333780	+	59	59		70		70	FALSE	FALSE		1	1	½ Ig #63
77	74	chr1	228334512	228334544	+	60	60		71		71	FALSE	FALSE		1	1	-
78	75	chr1	228334815	228334913	+	61	61		72		72	FALSE	FALSE		1	1	½ Ig #64
79	76	chr1	228335080	228335298	+	62	62		73		73	FALSE	FALSE		1	1	½ Ig #64
80	77	chr1	228335791	228335851	+	63	63		74		74	FALSE	FALSE		1	2	-
81	78	chr1	228336200	228336270	+	64	64		75		75	FALSE	FALSE		2	1	-
82	79	chr1	228337004	228337126	+	65	65		76		76	FALSE	FALSE		1	1	-
83	80	chr1	228337244	228337383	+	66	66		77		77	FALSE	FALSE		1	0	-
84	81	chr1	228337944	228338144	+	67	67		78		78	FALSE	FALSE		0	0	SH3
85	82	chr1	228338290	228338372	+	68	68		79		79	FALSE	FALSE		0	2	-
86	83	chr1	228338853	228339026	+	69	69		80		80	FALSE	FALSE		2	2	DH
87	84	chr1	228339945	228340101	+	70	70		81		81	FALSE	FALSE		2	0	DH
88	85	chr1	228340506	228340622	+	71	71		82		82	FALSE	FALSE		0	0	DH
89	86	chr1	228340724	228340888	+	72	72		83		83	FALSE	FALSE		0	0	DH
90	87	chr1	228341095	228341253	+	73	73		84		84	FALSE	FALSE		0	0	PH
91	88	chr1	228341437	228341614	+	74	74		85		85	FALSE	FALSE		0	1	PH
92	89	chr1	228342119	228342232	+	75	75		86		86	FALSE	FALSE		1	1	½ Ig #65
93	90	chr1	228349890	228350057	+	76	76		87		87	FALSE	FALSE		1	1	½Ig #65
94	91	chr1	228350841	228350943	+	77	77		88		88	FALSE	FALSE		1	2	1/3 Ig #66
95	92	chr1	228351321	228351450	+	78	78		89		89	FALSE	FALSE		2	0	1/3 Ig #66
96	93	chr1	228352951	228353062	+	79	79		90		90	FALSE	FALSE		0	1	1/3 Ig #66
97	94	chr1	228356151	228356193	+	80						FALSE	FALSE		1	2	-
98	95	chr1	228359597	228361250	+	81						FALSE	TRUE	AL=chr1:228217395-228218222:+, AL=chr1:228378618-228378874:+, AL=chr1:228378618-228378876:+	2	-	-
99	96	chr1	228362576	228362755	+		80		91		91	FALSE	FALSE		1	1	-
100	97	chr1	228364981	228365077	+		81		92		92	FALSE	FALSE		1	2	-
101	98	chr1	228365436	228365560	+		82		93		93	FALSE	FALSE		2	1	-
102	99	chr1	228366074	228366186	+		83		94		94	FALSE	FALSE		1	0	½ Ig #67
103	100	chr1	228366400	228366568	+		84		95		95	FALSE	FALSE		0	1	½ Ig #67
104	101	chr1	228366808	228366889	+		85		96		96	FALSE	FALSE		1	2	Kinase #1
105	102	chr1	228366975	228367175	+		86		97		97	FALSE	FALSE		2	2	Kinase #1
106	103	chr1	228367886	228367946	+		87		98		98	FALSE	FALSE		2	0	Kinase #1
107	104	chr1	228368339	228368416	+		88		99		99	FALSE	FALSE		0	0	Kinase #1
108	105	chr1	228368722	228368894	+		89		100		100	FALSE	FALSE		0	2	Kinase #1
109	106	chr1	228369136	228369162	+		90		101		101	FALSE	FALSE		2	2	Kinase #1
110	107	chr1	228369942	228370094	+		91		102		102	FALSE	FALSE		2	2	Kinase #1
111	108	chr1	228370193	228370238	+		92		103		103	FALSE	FALSE		2	0	Kinase #1
112	109	chr1	228370679	228370756	+		93		104		104	FALSE	FALSE		0	0	-
113	110	chr1	228371023	228373081	+		94		105		105	FALSE	FALSE		0	1	-
114	111	chr1	228373932	228374012	+		95		106		106	FALSE	FALSE		1	1	-
115	112	chr1	228374314	228374424	+		96		107		107	FALSE	FALSE		1	1	½ Ig #68
116	113	chr1	228374585	228374752	+		97		108		108	FALSE	FALSE		1	1	½ Ig #68
117	114	chr1	228375702	228375824	+		98		109		109	FALSE	FALSE		1	1	-
118	115	chr1	228376008	228376178	+		99		110		110	FALSE	FALSE		1	1	-
119	116	chr1	228376793	228376874	+		100		111		111	FALSE	FALSE		1	2	Kinase #2
120	117	chr1	228377052	228377291	+		101		112		112	FALSE	FALSE		2	2	Kinase #2
121	118	chr1	228377489	228377712	+		102		113		113	FALSE	FALSE		2	1	Kinase #2
122	119	chr1	228377931	228378006	+		103				114	FALSE	FALSE	A5'=chr1:228377937-228378006:+	1	2	Kinase #2
123	119a	chr1	228377937	228378006	+				114			FALSE	FALSE	A5'=chr1:228377931-228378006:+	1	2	Kinase #2
124	120	chr1	228378271	228378420	+		104		115		115	FALSE	FALSE		2	2	Kinase #2
125	121a	chr1	228378618	228378874	+		105					FALSE	TRUE	AL=chr1:228217395-228218222:+, AL=chr1:228359597-228361250:+, AL=chr1:228378618-228378876:+	2	-	Kinase #2
126	121	chr1	228378618	228378876	+				116		116	FALSE	TRUE	AL=chr1:228217395-228218222:+, AL=chr1:228359597-228361250:+, AL=chr1:228378618-228378874:+	2	-	Kinase #2

Each row of the table represents a unique OBSCN exon. The unique exon IDs based on the non-overlapping exons are listed below the “Meta-transcript exon number”. The six studied transcripts include ENST00000284548, ENST00000422127, ENST00000570156, ENST00000680850, ENST00000660857 and ENST00000493977. Below the columns labelled with the Ensembl IDs, for those exons included in the isoform, the number of the exons are stated. In the columns labelled with “First exon” and “Last exon”, the cells corresponding to the first and last exon of the isoform are marked with TRUE. The final fours columns (i.e. on the right) include the detailed information about the alternative splicing events, and the annotated domains

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ISSN: 2044-5040

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