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Fig. 1 | Skeletal Muscle

Fig. 1

From: Aminoguanidine hemisulfate improves mitochondrial autophagy, oxidative stress, and muscle force in Duchenne muscular dystrophy via the AKT/FOXO1 pathway in mdx mice

Fig. 1

Impact of AGH treatment on autophagy and mitochondrial homeostasis in the tibialis anterior (TA) muscles of mdx mice. TA from wild-type (WT), mdx, and AGH-treatment mdx mice were isolated at 8 weeks of age (A–E) Representative blots and quantification for LC3, p62, and Pink1. Quantitatifications were normalized to β-tubulin level. Gene expression levels of (F) mitochondrial DNA, (G) mitophagy, (H) mitochondrial dynamics, and (I) biogenesis markers were measured using real-time PCR. Values were normalized to 36B4 for each target. Values are presented as the mean ± standard error of the mean for each experiment (n = 5). * p < 0.05 compared with WT control, # p < 0.05 compared with mdx

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Skeletal Muscle

ISSN: 2044-5040

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