Fig. 6
From: Sarcolemma resilience and skeletal muscle health require O-mannosylation of dystroglycan
Skeletal muscle health requires matriglycan. A Schematic of DG core M glycans in control and Large1skm mice. B Immunofluorescence of skeletal muscle to detect matriglycan (recombinant rabbit IIH6 antibody) in control and Large1skm mice. Images shown at 40X magnification. Scale bar = 100 µm. C Body weights of 20-week-old control and Large1skm mice. **** < 0.0001. D Serum creatine kinase (CK) activity two hours after treadmill exercise. ** = 0.0016. E Specific force determined by ex vivo maximum isometric tetanic contractions of the EDL muscle. F Ex vivo analysis of force in EDL muscles following eccentric contractions. N = 4 per group. G In vivo dynamic torque production by plantar flexors. **** < 0.0001. H Isometric torque as a measure of the response of plantar flexors to repeated eccentric contractions. N = 5 CON; N = 6 Large1skm. Data expressed as mean ± standard deviation. P-values determined by unpaired t-test with Holm-Sidak post-hoc analysis