Fig. 4
From: Sarcolemma resilience and skeletal muscle health require O-mannosylation of dystroglycan
POMT1 is required in skeletal muscle for neuromuscular function. A and B Ex vivo maximum isometric tetanic contractions of the extensor digitorum longus (EDL) from control and Pomt1skm mice to detect A) absolute force and B) specific force indicating absolute force relative to the estimated cross-sectional area of the EDL muscle N = 4 per group. C Neuromuscular strength assessed through forelimb grip strength testing in control mice and age- and gender-matched Pomt1skm mice at four, eight, and 12 weeks of age. Males: ** = 0.0030; **** < 0.0001. Females: **** < 0.0001. D Neuromotor coordination and skeletal muscle endurance assessed through wire hang experiment. **** < 0.0001. E Plantar flexor torque produced during dynamic movement from in vivo electrical stimulation. *** = 0.0002. For all statistical analyses, unpaired t-tests with Holm-Sidak post-hoc analysis were performed. Data expressed as mean ± standard deviation