Fig. 3
From: Sarcolemma resilience and skeletal muscle health require O-mannosylation of dystroglycan
Skeletal muscle mass and fiber diameter are influenced by O-mannosylation of α-DG. A Skeletal muscle mass for gastrocnemius (Gast) muscle tissue from 13-week-old male control mice and age- and gender-matched Pomt1skm mice. N = 4 / group. B Hematoxylin and eosin (H&E) stained transverse cross-sections from gastrocnemius muscles obtained from control or Pomt1skm mice. Images captured with 20X objective. Scale bar = 50 µm. C and D Anti-perlecan-stained immunofluorescent images obtained from transverse cross-sections of the mid-belly of gastrocnemius muscles from control and Pomt1.skm mice (C). Minimal (min) Feret’s diameter determined from anti-perlecan images (D). N = 4 per group. Data expressed as mean ± standard deviation. P-values determined by unpaired t-test with Holm-Sidak post-hoc analysis. Gast * = 0.0037. Min. Feret’s Diameter *** = 0.0002