Fig. 1
From: Sarcolemma resilience and skeletal muscle health require O-mannosylation of dystroglycan
Biosynthesis of core M glycans on α-DG. A The α-DG O-mannosyl glycosylation pathway is depicted, highlighting the synthesis of core M1, M2, and M3 glycans. B Schematic depicts O-mannosylated DG situated at the sarcolemma and its interaction with ECM ligands. Abbreviations: Man, mannose; GlcNAc, N-acetylglucosamine; Gal, galactose; GalNAc, N-acetylgalactosamine; Xyl, xylose; GlcA, glucuronic acid; POMT1/2, protein O-mannosyltransferases 1 and 2; POMGNT1, protein O-linked mannose N-acetyl-glucosaminyltransferase 1; MGAT5B, mannosyl α1,6-glycoprotein β1,6,-N-acetyl-glucosaminyltransferase; POMGNT2, protein O-linked mannose N-acetyl-glucosaminyltransferase 2; B3GALNT2, β1,3-N-acetylgalactosaminyltransferase 2; POMK, protein O-mannose kinase; FKTN, Fukutin; FKRP, Fukutin related protein; RXYLT1, ribitol xylosyltransferase 1; TMEM5, transmembrane protein 5; B4GAT1, β1,4-glucuronyltransferase 1; LARGE1, like-acetyl-glucosaminyltransferase 1