Fig. 9

Muscle-specific deletion of GLUT4 reduces the number of centrally nucleated myofibers post BaCl₂-induced injury. In 13–14 week old, male control (CON) and muscle-specific GLUT4 knockout (mG4KO) mice, BaCl₂ solution was injected into the muscles of one leg. The contralateral leg was not injected. Quantification of the percentage of myofibers with centralized nuclei in muscles from mice euthanized at (A) 7 days (N = 4–6 muscles/group), and (B) 14 days post-injection (N = 6–7 muscles/group). Data are presented as individual data points plus the mean ± standard deviation. Statistical significance was defined as P < 0.05, determined by Two-Way ANOVA with Tukey’s posthoc analysis, and denoted by ‘*’ vs. non-injected control muscle (-), and ‘#’ vs. CON mice