Fig. 1

Skeletal muscle atrophy observed in the SAP mouse model induced by pancreatic duct ligation (PDL). (A) Experimental protocol for establishing the SAP mouse model by PDL. (B) Survival rate of SAP mice. (C) Representative images of pancreatic and muscle tissue H&E staining in SAP mice. (D) Percentage of weight loss in SAP mice. (E, F) The mRNA levels of MURF-1 and MAFb-x in muscle tissues of SAP mice. N ≥ 4, ns p ≥ 0.05, * p<0.05, **p<0.01, ***p<0.001