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Fig. 3 | Skeletal Muscle

Fig. 3

From: SIX transcription factors are necessary for the activation of DUX4 expression in facioscapulohumeral muscular dystrophy

Fig. 3

Involvement of SIX coactivator, EYA, in DUX4 regulation. FSHD1 (54–2) myoblasts were transfected with EYA1, EYA3 and EYA4 and differentiated to form multinucleated myotubes. Shown are the relative mRNA levels from qPCR for (A-B) DUX4, A-B DUX4 targets (MBD3L2, LEUTX and ZSCAN4) and C each EYA target. Each experimental group (n = 3) was normalized to a negative si-Control with the mean and standard deviation depicted. Asterisks demonstrate statistical significance between the control vs experimental group using an unpaired two tailed t-test (ns = not significant; *p < 0.05)

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Skeletal Muscle

ISSN: 2044-5040

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