Fig. 1

Transverse aortic constriction (TAC)-induced heart failure decreases body weight and increases heart weight. C57BL/6J mice were subjected to sham or TAC surgeries for 4, 8 or 14 weeks. (A) Body weight and (B) heart weight were normalized to tibia length. Data are presented as mean ± SEM; n = 6–10 mice in each group; *p < 0.05 vs sham