Table 1 Genetic fly lines used in this study

w¹¹¹⁸

Gift from Dr. Young Kwon, Harvard Medical School

w[1118]

Used as a reference line in aging experiments

y w

Gift from Dr. Richard Cripps, University of Sand Diego

y[*] w[*]

DGRP-21

BDSC 28122

Inbred wild-type strain

DGRP-31

BDSC 55014

Inbred wild-type strain

DGRP-41

BDSC 28126

Inbred wild-type strain

DGRP-45

BDSC 28128

Inbred wild-type strain

DGRP-57

BDSC 29652

Inbred wild-type strain

DGRP-59

BDSC 28129

Inbred wild-type strain

DGRP-75

BDSC 28132

Inbred wild-type strain

DGRP-85

BDSC 28274

Inbred wild-type strain

DGRP-88

BDSC 28135

Inbred wild-type strain

DGRP-91

BDSC 28136

Inbred wild-type strain

DGRP-93

BDSC 28137

Inbred wild-type strain

DGRP-101

BDSC 28138

Inbred wild-type strain

DGRP-105

BDSC 28139

Inbred wild-type strain

DGRP-109

BDSC 28140

Inbred wild-type strain

DGRP-136

BDSC 28142

Inbred wild-type strain

DGRP-142

BDSC 28144

Inbred wild-type strain

DGRP-149

BDSC 28145

Inbred wild-type strain

DGRP-153

BDSC 28146

Inbred wild-type strain

DGRP-158

BDSC 28147

Inbred wild-type strain

DGRP-161

BDSC 28148

Inbred wild-type strain

DGRP-177

BDSC 28150

Inbred wild-type strain

DGRP-208

BDSC 25174

Inbred wild-type strain

DGRP-287

BDSC 28165

Inbred wild-type strain

DGRP-303

BDSC 25176

Inbred wild-type strain

DGRP-306

BDSC 37525

Inbred wild-type strain

DGRP-307

BDSC 25179

Inbred wild-type strain

DGRP-309

BDSC 28166

Inbred wild-type strain

DGRP-310

BDSC 28276

Inbred wild-type strain

DGRP-313

BDSC 25180

Inbred wild-type strain

DGRP-318

BDSC 28168

Inbred wild-type strain

DGRP-319

BDSC 55018

Inbred wild-type strain

DGRP-320

BDSC 29654

Inbred wild-type strain

DGRP-324

BDSC 25182

Inbred wild-type strain

DGRP-332

BDSC 28171

Inbred wild-type strain

DGRP-336

BDSC 28172

Inbred wild-type strain

DGRP-338

BDSC 28173

Inbred wild-type strain

DGRP-340

BDSC 28174

Inbred wild-type strain

DGRP-348

BDSC 55019

Inbred wild-type strain

DGRP-350

BDSC 28176

Inbred wild-type strain

DGRP-360

BDSC 25186

Inbred wild-type strain

DGRP-382

BDSC 28189

Inbred wild-type strain

DGRP-409

BDSC 28278

Inbred wild-type strain

DGRP-820

BDSC 25208

Inbred wild-type strain

DGRP-852

BDSC 25209

Inbred wild-type strain

79B6

[24]

w[1118] P(w[+ mC] = Act79B-Gal4)6

TDT-specific driver for the Gal4/UAS system, employed in TDT-specific knockdowns

elav-Gal4

BDSC 458

P([+ mW.hs] = GawB)elav[C155]

Neuron-specific driver for the Gal4/UAS system, employed in KD^NEU flies

Mef2-Gal4

Gift from Dr. Aaron Johnson, Washington University in St. Louis

w[*];P(w[+ m*] = Mef2-Gal4)3

Muscle-specific driver for the Gal4/UAS system, used in KD^MUS and mito-GFP flies

Ca-α1D KD

BDSC 33413

y[1] v[1]; P(y[+ t7.7] v[+ t1.8] = TRiP.HMS00294)attP2

Induces Ca-α1D RNAi knockdown

jus KD

BDSC 28764

y[1] v[1]; P(y[+ t7.7] v[+ t1.8] = TRiP.JF03192)attP2

Induces jus RNAi knockdown

attP2

BDSC 36303

y[1] v[1]; P(y[+ t7.7] = CaryP)attP2

Control for RNAi knockdown crosses

mito-GFP

BDSC 8442

w[1118]; P(w[+ mC] = UAS-mito-HA-GFP.AP)2/CyO

Expresses mitochondrial fluorescent marker [25]