Fig. 6

Progressive degeneration of the aging TDT muscle. A Changes in live TDT fiber counts within a population of aging w¹¹¹⁸ flies. Statistically significant changes are detected in 5 week old (wo) flies. B Jump test results obtained from the w¹¹¹⁸ flies of different ages. “Non-jumpers” denotes flies that cannot jump. The jumping ability significantly declines in 5 wo flies. Statistical significance by Kruskal–Wallis test (left panel) and Fisher’s exact test (right panel): (***) p < 0.001. C Scatter plot of TDT degeneration scores vs population mortality for 43 DGRP wild-type inbred fly strains reared at 29 °C for 4 weeks. A linear regression line with correlation coefficient (r) is shown. Lines that are analyzed in D are shown in grey color. D Examples of two DGRP lines with comparable survivorship at 4 weeks (13%), but drastically different degeneration scores in the TDT muscle. Statistical significance by Fisher’s Exact Test: (**) p < 0.01