Fig. 4
From: Skeletal muscle vulnerability in a child with Pitt-Hopkins syndrome
Proteomic studies on whole protein extract of TCF4-mutant muscle. A Schematic representation of the applied workflow. B Overall statistics of PTHS skeletal muscle proteomics. C Volcano plot showing proteins identified as being decreased (orange dots) and increased (purple dots) in PTHS patient-derived muscle. D Results of proteomaps-based data analysis indicating activation of complement cascade and altered oxidative phosphorylation based on identified protein dysregulations