Skip to main content
Fig. 4 | Skeletal Muscle

Fig. 4

From: Cellular and molecular alterations to muscles and neuromuscular synapses in a mouse model of MEGF10-related myopathy

Fig. 4

Ultrastructural abnormalities in Megf10 KO NMJs. (A-B) Representative transmission electron micrographs of NMJs in cross sections from young adult (6 mo) female WT and Megf10 KO extensor digitorum longus (EDL) muscles. (A) WT NMJs with the labels for synaptic vesicles (sv), the synaptic cleft (sc), mitochondria (mi), and junctional folds (jf). (B) Megf10 KO NMJ showing loss of junctional folds on the postsynapse (*) and intrusion of PSC processes into the synaptic cleft (arrow). Density of (C) synaptic vesicles in the presynapse, (D) mitochondria in the presynapse, and (E) mitochondria in the postsynapse are quantified, with red horizontal lines indicating means. Scale bars are 1 Î¼m. n = 1, ∼ 30 NMJs analyzed per mouse

Back to article page

Skeletal Muscle

ISSN: 2044-5040

Contact us