Fig. 5

Panx1^−/−/mdx mice Display Reduced Muscle Strength and Locomotor Function. The soleus muscle was subjected to force measurements and the A) force-frequency curves were recorded with the B) average maximum force determined based on the curves (n = 7; two-tailed unpaired student’s t-test). C Mean forelimb grip strength of Panx1^−/−/mdx and Panx1^+/+/mdx mice was measured (n = 8–9; two-tailed unpaired student’s t-test). Mice were also subjected to a pole test where the D) time to turn around and E) time to descend the pole were measured (n = 9–10; two-tailed unpaired student’s t-test). Data represents mean ± s.d. except for panel A where data represents mean ± s.e.m. to better visualize the curves. * P < 0.05, ** P < 0.01