Fig. 2

Panx1^−/−/mdx mice Have a Reduced Life Span, Body Weight, and Lean Mass. A Survival curve of Panx1^−/−/mdx and Panx1^+/+/mdx mice (n = 15; Log-rank test). B Total body weight of Panx1^−/−/mdx and Panx1^+/+/mdx mice from 3–12 months of age (n = 8–15; two-tailed unpaired student’s t-tests for each time point). EchoMRI analysis displaying the C) total body weight, D) lean mass and E) fat mass of 3 month old mice (n = 10; two-tailed unpaired student’s t-test), F) total body weight, G) lean mass and H) fat mass respectively for 6 month old mice (n = 8; two-tailed unpaired student’s t-test) and I) total body weight, J) lean mass and K) fat mass respectively for 12 month old mice (n = 7–8; two-tailed unpaired student’s t-test). Data represents mean ± s.d., except for panel B that is shown as mean ± s.e.m. * P < 0.05, ** P < 0.01, *** P < 0.001, ns: non-significant