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Fig. 2 | Skeletal Muscle

Fig. 2

From: Eldecalcitol prevents muscle loss and osteoporosis in disuse muscle atrophy via NF-κB signaling in mice

Fig. 2

Eldecalcitol inhibited the reduction of muscle cross-sectional area and the expression of muscle atrophy protein markers. a–c H&E stating of GAS muscle and analysis of muscle cross-sectional area. d–g Eldecalcitol decreased the protein expression levels of Atrogin-1 and MuRF-1 and increased the protein expression levels of MyHC. h–i mRNA levels of Atrogin-1 and MuRF-1 by qPCR. Values are presented as mean ± SEM (n = 8). *P < 0.05; **P < 0.01; ***P < 0.001 vs. Con; #P < 0.05; ##P < 0.01; ###P < 0.001 vs. TS. Con, control; CSA, cross-sectional area; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; ELD, eldecalcitol; TS, tail suspension; MyHC; myosin heavy chain; SEM, standard error of mean

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Skeletal Muscle

ISSN: 2044-5040

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