Fig. 1

Elevated expression of heart failure markers in SMA model mice. qRT-PCR analysis of a BNP and b ACTA1 mRNA expression. Expression levels (mean ± SEM) in SMN-deficient (SMA) heart tissue are represented relative to unaffected controls at each time point. Statistical analysis: p values shown for one-way ANOVA, Tukey’s post hoc test, n = 7