Fig. 1

Physical characteristics of NaCl- or monocrotaline (MCT)-treated C57BL/6 wild-type animals or MuRF1 and MuRF2 knockout animals. When compared to the NaCl-treated animals, the administration of MCT to the animals had significant effects on final body weight (a), lung weight (b), heart weight (c), and the thickness of the right ventricle (d) independent of the phenotype. Data are presented as mean ± SEM