Fig. 1

Copolymer-based muscle membrane stabilization of dystrophic muscle. a Representation of intact muscle membrane with dystrophin anchoring the DGC to the actin cytoskeleton. b Membrane instability caused by the lack of dystrophin leads to pathological increases in intracellular Ca²⁺ concentration. c Copolymer stabilization of the damaged membrane via insertion of its hydrophobic PPO block (red) prevents entry of extracellular Ca²⁺ into the cell