Fig. 2

Neurite bundles and migrating neurons from organotypic DRG explants. 2-1 a–e The neurite bundles (> 200 μm in length) in the superior lateral quadrant were counted in each sample. 2-1 a NRG-1β. 2-1 b NRG-1β + PD98059. 2-1 c NRG-1β + LY294002. 2-1 d NRG-1β + AG490. 2-1 e control. Scale bar = 50 μm. 2-1 f Quantification of the number of nerve fiber bundles. Mean ± SD, n = 5. *P < 0.05, **P < 0.01, ***P < 0.001. 2-2 a–e The migrating neurons from organotypic DRG explants in different conditions. 2-2 a NRG-1β. 2-2 b NRG-1β + PD98059. 2-2 c NRG-1β + LY294002. 2-2 d NRG-1β + AG490. 2-2 e control. Scale bar = 50 μm. 2-2 f Quantification of the migrating neurons from DRG explants. Mean ± SD, n = 5. *P < 0.05, ***P < 0.001