Fig. 5

MKP-5-deficient mice exhibit increased Bcl-2 expression in regenerating skeletal muscle. Expression of Bcl-2 protein in mkp-5 ^+/+ and mkp-5 ^−/− mice was determined by immunoblotting with anti-Bcl2 antibodies in muscle lysates prepared from (a) uninjured and (b) 10 days after CTX-induced injury. The graphs represent quantitation of Bcl-2 immunoblots normalized to Erk1/2 expression. Values are means ± standard errors of the means (SEM). **P < 0.01, n = 5 per genotype