Fig. 1
Dysregulation of complement components in tibialis anterior muscle (TA) of hSOD1G93A mice at three different stages of disease progression. Panels a to f show the mRNA expression profiles of the following complement components: C1qB (a, classical pathway), C4 (b, classical/lectin pathway), fB (c, alternative pathway), C3 (d, central component), CD55 (e, regulator), and CD59a (f, regulator) in TA muscle of hSOD1G93A mice (SOD1, black bars) relative to wild-type (WT, white bars) mice during onset (OS; postnatal day 70 (P70)), mid-symptomatic (MS; postnatal day 130 (P130)) and end-stage of disease (ES; postnatal day 175 (P175)). Data are expressed as means ± SEM (n = 5 mice/group, * p < 0.05, ** p < 0.01, Student t test 6)