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Figure 5 | Skeletal Muscle

Figure 5

From: Inhibition of extracellular signal-regulated kinase 1/2 signaling has beneficial effects on skeletal muscle in a mouse model of Emery-Dreifuss muscular dystrophy caused by lamin A/C gene mutation

Figure 5

Selumetinib inhibits ERK1/2 phosphorylation in skeletal muscles from LmnaH222P/H222Pmice. Representative immunoblots using antibodies against phosphorylated ERK1/2 (pERK1/2) and total ERK1/2 (ERK1/2) to probe proteins extracts from quadriceps, diaphragm, and tibialis anterior from 20-week-old male LmnaH222P/H222P mice treated with selumetinib or DMSO for 4 weeks. The immunoblot shown is representative of three separately performed experiments.

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Skeletal Muscle

ISSN: 2044-5040

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