Figure 3
From: Skeletal muscle laminin and MDC1A: pathogenesis and treatment strategies
Laminin-211 receptors in muscle and their binding sites on the laminin α2 chain. Laminin α2 subunit binds dystroglycan and integrin α7β1 via the laminin globular (LG) domains. LG1 to 3 and 4 to 5 bind α-dystroglycan, whereas only LG1 to 3 binds integrin α7β1. Glycosylation of α-dystroglycan is important for laminin binding.